Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef

@inproceedings{Breuer2011MolecularDF,
  title={Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef},
  author={Sebastian Breuer and Simone I. Schievink and Antje Schulte and Wulf Blankenfeldt and Oliver T. Fackler and Matthias Geyer},
  booktitle={PloS one},
  year={2011}
}
Increased spread of HIV-1 and rapid emergence of drug resistance warrants development of novel antiviral strategies. Nef, a critical viral pathogenicity factor that interacts with host cell factors but lacks enzymatic activity, is not targeted by current antiviral measures. Here we inhibit Nef function by simultaneously blocking several highly conserved protein interaction surfaces. This strategy, referred to as "wrapping Nef", is based on structure-function analyses that led to the… CONTINUE READING
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