Molecular Coupling of S4 to a K+ Channel's Slow Inactivation Gate

  title={Molecular Coupling of S4 to a K+ Channel's Slow Inactivation Gate},
  author={Eli Loots and Ehud Y Isacoff},
  journal={The Journal of General Physiology},
  pages={623 - 636}
The mechanism by which physiological signals regulate the conformation of molecular gates that open and close ion channels is poorly understood. Voltage clamp fluorometry was used to ask how the voltage-sensing S4 transmembrane domain is coupled to the slow inactivation gate in the pore domain of the Shaker K(+) channel. Fluorophores attached at several sites in S4 indicate that the voltage-sensing rearrangements are followed by an additional inactivation motion. Fluorophores attached at the… CONTINUE READING

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