Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study.

Abstract

Macrophages provide the first line of host immune defense. Their activation triggers the secretion of pro-inflammatory cytokines and chemokines recruiting other immune cells. In cancer, macrophages present an M2 anti-inflammatory phenotype promoting tumor growth. In this way, strategies need to be develop to reactivate macrophages. Previously thought to be… (More)
DOI: 10.1074/mcp.M115.052480

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Cite this paper

@article{Duhamel2015MolecularCO, title={Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study.}, author={Marie Duhamel and Franck Rodet and Nadira Delhem and Fabien Vanden Abeele and Firas H. Kobeissy and Serge Nataf and Laurent Pays and Roxanne Desjardins and Hugo Gagnon and Maxence Wisztorski and Isabelle Fournier and Robert Day and Michel Salzet}, journal={Molecular & cellular proteomics : MCP}, year={2015}, volume={14 11}, pages={2857-77} }