Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment

  title={Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment},
  author={Calvin R. Justus and Edward J. Sanderlin and Li V Yang and William Chi-shing Cho},
  booktitle={International journal of molecular sciences},
Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the "Warburg effect", commonly exists in a variety of tumors. Recent studies further demonstrate that both genetic factors such as oncogenes and tumor suppressors and microenvironmental factors such as spatial hypoxia and acidosis can regulate the glycolytic metabolism of cancer cells. Reciprocally, altered… CONTINUE READING
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