Perspectives on theory at the interface of physics and biology
- PhysicsReports on progress in physics. Physical Society
I am an optimist, and believe that the time is ripe for the emergence of a more unified theoretical physics of biological systems, building on successes in thinking about particular phenomena.
Making Sense of Genes
Making Sense of Genes is an accessible but rigorous introduction to contemporary genetics concepts for non-experts, undergraduate students, teachers and healthcare professionals.
Theoretical Analysis of Competing Conformational Transitions in Superhelical DNA
- BiologyPLoS Comput. Biol.
A statistical mechanical model is developed to analyze the competitive behavior of transitions to multiple alternate conformations in a negatively supercoiled DNA molecule of kilobase length and specified base sequence and shows this competition to be highly sensitive to temperature and to the imposed level of supercoiling.
Beyond the double helix: DNA structural diversity and the PDB
- Chemistry, BiologyThe Journal of biological chemistry
Alternative DNA Structures In Vivo: Molecular Evidence and Remaining Questions
- Biology, ChemistryMicrobiology and Molecular Biology Reviews
Evidence supporting the formation of alternative DNA structures in vivo is discussed and the role of the mismatch repair machinery in binding mispaired DNA duplexes, triggering genetic instability is emphasized.
Through the Looking Glass: The AADR and the Wow of Science
- ArtJournal of dental research
In Through the Looking Glass, Lewis Carroll uses a 2-way mirror as a metaphor for seeing ourselves existing in reality while also transporting into our imaginations (Fig. 1). In our imaginations,…
Studies towards the prebiotic synthesis and phosphorylation of ribonucleotides
- Biology, Chemistry
The discovery of a generational node in the network of prebiotic chemistry that links the syntheses of amino acids with nucleotides 5'-phosphates suggests that these different groups of metabolites need not have arisen from separate chemistries, helping to get a better understanding of the processes governing the chemical evolution of life.
Cellular Detection of G‐Quadruplexes by Optical Imaging Methods
- Biology, ChemistryCurrent protocols in cell biology
A repertoire of protocols that have developed over the past years to visualize quadruplexes in cells are listed, thanks to the discovery of a novel family of versatile quadruplex‐selective fluorophores, the twice‐as‐smart quadruplex ligands named TASQ (for template‐assembled synthetic G‐quartet).
The scrunchworm hypothesis: transitions between A-DNA and B-DNA provide the driving force for genome packaging in double-stranded DNA bacteriophages.
- BiologyJournal of structural biology
SHOWING 1-3 OF 3 REFERENCES
A Proposed Structure For The Nucleic Acids.
- BiologyProceedings of the National Academy of Sciences of the United States of America
The proposed structure for the Nucleic Acids is based on X-ray diffraction analysis of Na6(CO3, Na3SO4, Na2SO3, and Na2CO4 using a Higgs boson-like structure.
The structures of nucleic acids.
- Biology, ChemistrySymposia of the Society for Experimental Biology
The structure of proteins; two hydrogen-bonded helical configurations of the polypeptide chain.
- ChemistryProceedings of the National Academy of Sciences of the United States of America
This work has used information about interatomic distances, bond angles, and other configurational parameters to construct two reasonable hydrogen-bonded helical configurations for the polypeptide chain; it is likely that these configurations constitute an important part of the structure of both fibrous and globular proteins, as well as of syntheticpolypeptides.