Molecular Cloning and Functional Characterization of Tibetan Porcine STING

@inproceedings{Huang2012MolecularCA,
  title={Molecular Cloning and Functional Characterization of Tibetan Porcine STING},
  author={Zhiqing Huang and Xiaoling Chen and Keying Zhang and Bing Yu and Xiangbing Mao and Ye Zhao and Daiwen Chen},
  booktitle={International journal of molecular sciences},
  year={2012}
}
Tibetan pig is well known for its strong disease resistance. However, little is known about the molecular basis of its strong resistance to disease. Stimulator of interferon (IFN) genes (STING), also known as MPYS/MITA/ERIS/TMEM173, is an adaptor that functions downstream of RIG-I and MAVS and upstream of TBK1 and plays a critical role in type I IFN induction. Here we report the first cloning and characterization of STING gene from Tibetan pig. The entire open reading frame (ORF) of the Tibetan… CONTINUE READING

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