Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent

@article{Linnen1996MolecularCA,
  title={Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent},
  author={Jeffrey M. Linnen and John M. Wages and Z Y Zhang-Keck and Kirk E. Fry and Krzysztof Krawczyński and Harvey J. Alter and Eugene Koonin and Margaret L. Gallagher and Miriam J. Alter and Stephanos J. Hadziyannis and Peter Karayiannis and Kevin Fung and Yoshiyuki Nakatsuji and J. Wai-Kuo Shih and L M Young and Michael Piatak and Cameron C. Hoover and John Fernandez and Stacie Chen and Jian-Chao Zou and T T Morris and Kenneth Craig Hyams and Susan L Ismay and Jeffrey D. Lifson and Georg Hess and Steven K. H. Foung and Howard Thomas and Daniel W. Bradley and Harold S. Margolis and Jungsuh P. Kim},
  journal={Science},
  year={1996},
  volume={271},
  pages={505 - 508}
}
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with… 
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