• DOI:10.1126/science.271.5248.505
Corpus ID: 12931655

Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent

@article{Linnen1996MolecularCA,
  title={Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent},
  author={J. Linnen and J. Wages and Z. Zhang-Keck and K. Fry and K. Krawczynski and H. Alter and E. Koonin and M. Gallagher and M. Alter and S. Hadziyannis and P. Karayiannis and K. Fung and Y. Nakatsuji and J. Shih and L. Young and M. Piatak and C. Hoover and J. Fern{\'a}ndez and S. Chen and J. Zou and T. Morris and K. Hyams and S. Ismay and J. Lifson and G. Hess and S. Foung and H. Thomas and D. Bradley and H. Margolis and J. Kim},
  journal={Science},
  year={1996},
  volume={271},
  pages={505 - 508}
}

• J. Linnen, J. Wages, +27 authors J. Kim
• Published 1996
• Biology, Medicine
• Science

An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with… Expand