Molecular Cloning, Characterisation and Tissue-specific Expression of Human LAG3, a Member of the Novel Lag1 Protein Family

@article{Cai2003MolecularCC,
  title={Molecular Cloning, Characterisation and Tissue-specific Expression of Human LAG3, a Member of the Novel Lag1 Protein Family},
  author={Xing-Feng Cai and Zhen Tao and Zhi-qiang Yan and Sheng-Li Yang and Yi Gong},
  journal={DNA Sequence},
  year={2003},
  volume={14},
  pages={79 - 86}
}
We identified and characterised the cDNA coding for human Lag3, a member of the novel eukaryotic Lag1 protein family which was related to the Saccharomyces cerevisiae longevity-assurance gene LAG1. The composite nucleotide sequence revealed a coding region of 1140 bp, a 5'-UTR of 210 bp and a 3'-UTR of 900 bp. The deduced sequence of 380 amino acids had six transmembrane regions and the conserved Lag1 motif. Northern blot analysis revealed that the ~2.2 kb LAG3Hs transcript was expressed in all… Expand
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