Corpus ID: 7432975

Molecular Characterization of the Vasculature of Patients with Infiltrating Ductal Carcinoma Generates a Gene Signature Predictive of Breast Cancer Survival

  title={Molecular Characterization of the Vasculature of Patients with Infiltrating Ductal Carcinoma Generates a Gene Signature Predictive of Breast Cancer Survival},
  author={Phuong Uyen Le and J. Li and Christiane Cantin and Catherine Collins and Andr{\'e} Nantel and Tammy-Lynn Tremblay and John F Kelly and Edwin Wang and Maureen D. O’Connor-McCourt and Anne E. G. Lenferink},
Targeting of the tumor vasculature has evolved into an integral part of existing standard anti-cancer therapies. However, recent pre-clinical and clinical studies have shown that the efficacy of these treatments is often temporary and frequently followed by renewed tumor growth. In an attempt to overcome this problem we transcriptionally profiled laser capture micro dissected micro vessels from both tumor and matching adjacent normal breast tissue obtained from patients diagnosed with… Expand
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