Molecular Characterization of the Dendritic Growth Cone: Regulated mRNA Transport and Local Protein Synthesis

@article{Crino1996MolecularCO,
  title={Molecular Characterization of the Dendritic Growth Cone: Regulated mRNA Transport and Local Protein Synthesis},
  author={Peter B. Crino and James Eberwine},
  journal={Neuron},
  year={1996},
  volume={17},
  pages={1173-1187}
}
The molecular mechanisms that regulate growth cone guidance of dendrite outgrowth remain to be elucidated. We hypothesized that mRNA localization in dendritic growth cones and their local protein synthesis may be important for growth cone functioning. The appearance of 23 of 31 growth cone mRNAs was developmentally regulated. Also, alteration of growth cone morphology affected the relative levels of three mRNAs. Finally, using single dendrite transfection, it was shown that local protein… CONTINUE READING
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