Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites*

@inproceedings{Artz2011MolecularCO,
  title={Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites*},
  author={Jennifer D. Artz and Amy K. Wernimont and James E Dunford and Matthieu Schapira and Aiping Dong and Yong Zhi Zhao and Jocelyne M. Lew and R Graham Russell and Frank H. Ebetino and Udo C. T. Oppermann and Raymond Hui},
  booktitle={The Journal of biological chemistry},
  year={2011}
}
We present here a study of a eukaryotic trans-prenylsynthase from the malaria pathogen Plasmodium vivax. Based on the results of biochemical assays and contrary to previous indications, this enzyme catalyzes the production of geranylgeranyl pyrophosphate (GGPP) rather than farnesyl pyrophosphate (FPP). Structural analysis shows that the product length is constrained by a hydrophobic cavity formed primarily by a set of residues from the same subunit as the product as well as at least one other… CONTINUE READING

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Modeling studies with Helicobacter pylori octaprenyl pyrophosphate synthase reveal the enzymatic mechanism of trans-prenyltransferases.

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