Molecular Characterization of a Human Matrix Attachment Region Epigenetic Regulator

@article{Arope2013MolecularCO,
  title={Molecular Characterization of a Human Matrix Attachment Region Epigenetic Regulator},
  author={S. Arope and Niamh Harraghy and M. Pjanic and N. Mermod},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
  • S. Arope, Niamh Harraghy, +1 author N. Mermod
  • Published 2013
  • Biology, Medicine
  • PLoS ONE
  • Matrix attachment regions (MAR) generally act as epigenetic regulatory sequences that increase gene expression, and they were proposed to partition chromosomes into loop-forming domains. However, their molecular mode of action remains poorly understood. Here, we assessed the possible contribution of the AT-rich core and adjacent transcription factor binding motifs to the transcription augmenting and anti-silencing effects of human MAR 1–68. Either flanking sequences together with the AT-rich… CONTINUE READING
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    References

    SHOWING 1-10 OF 47 REFERENCES
    Use of scaffold/matrix-attachment regions for protein production
    • 25
    Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells
    • 133
    • PDF
    Chromatin domains and prediction of MAR sequences.
    • T. Boulikas
    • Biology, Medicine
    • International review of cytology
    • 1995
    • 201
    Differential nuclear scaffold/matrix attachment marks expressed genes†
    • 58
    • PDF
    Chromatin loops are selectively anchored using scaffold/matrix-attachment regions
    • 183
    • PDF
    Biological significance of unwinding capability of nuclear matrix-associating DNAs.
    • 408