Molecular Characterization of a Human Matrix Attachment Region Epigenetic Regulator

  title={Molecular Characterization of a Human Matrix Attachment Region Epigenetic Regulator},
  author={S. Arope and Niamh Harraghy and M. Pjanic and N. Mermod},
  journal={PLoS ONE},
  • S. Arope, Niamh Harraghy, +1 author N. Mermod
  • Published 2013
  • Biology, Medicine
  • PLoS ONE
  • Matrix attachment regions (MAR) generally act as epigenetic regulatory sequences that increase gene expression, and they were proposed to partition chromosomes into loop-forming domains. However, their molecular mode of action remains poorly understood. Here, we assessed the possible contribution of the AT-rich core and adjacent transcription factor binding motifs to the transcription augmenting and anti-silencing effects of human MAR 1–68. Either flanking sequences together with the AT-rich… CONTINUE READING
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