Molecular Characterization of Trypanosoma cruzi SAP Proteins with Host-Cell Lysosome Exocytosis-Inducing Activity Required for Parasite Invasion

@inproceedings{Zanforlin2013MolecularCO,
  title={Molecular Characterization of Trypanosoma cruzi SAP Proteins with Host-Cell Lysosome Exocytosis-Inducing Activity Required for Parasite Invasion},
  author={Tamiris Zanforlin and Ethel Bayer-Santos and Cristian Cortez and Igor C. Almeida and Nobuko Yoshida and Jos{\'e} Franco da Silveira},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND To invade target cells, Trypanosoma cruzi metacyclic forms engage distinct sets of surface and secreted molecules that interact with host components. Serine-, alanine-, and proline-rich proteins (SAP) comprise a multigene family constituted of molecules with a high serine, alanine and proline residue content. SAP proteins have a central domain (SAP-CD) responsible for interaction with and invasion of mammalian cells by metacyclic forms. METHODS AND FINDINGS Using a 513 bp sequence… CONTINUE READING