Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila.

@article{Quaile2015MolecularCO,
  title={Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila.},
  author={Andrew T Quaile and Malene L. Urbanus and Peter J Stogios and Boguslaw P. Nocek and Tatiana Skarina and Alexander W Ensminger and Alexei Savchenko},
  journal={Structure},
  year={2015},
  volume={23 8},
  pages={1459-1469}
}
LubX is part of the large arsenal of effectors in Legionella pneumophila that are translocated into the host cytosol during infection. Despite such unique features as the presence of two U-box motifs and its targeting of another effector SidH, the molecular basis of LubX activity remains poorly understood. Here we show that the N terminus of LubX is able to activate an extended number of ubiquitin-conjugating (E2) enzymes including UBE2W, UBEL6, and all tested members of UBE2D and UBE2E… CONTINUE READING