Molecular Characterization of Iranian Patients with Possible Familial Hypercholesterolemia

@article{Farrokhi2011MolecularCO,
  title={Molecular Characterization of Iranian Patients with Possible Familial Hypercholesterolemia},
  author={Effat Farrokhi and F. Shayesteh and S. Asadi Mobarakeh and Farshad Roghani Dehkordi and Keihan Ghatreh Samani and Morteza Hashemzadeh Chaleshtori},
  journal={Indian Journal of Clinical Biochemistry},
  year={2011},
  volume={26},
  pages={244-248}
}
Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipoprotein metabolism caused mainly by mutations in the low-density lipoprotein receptor (LDLR) and apolipoprotein B 100 (APOB) genes. Until now, the molecular basis of FH has been demonstrated in detail in many populations, but there is still very limited Molecular data concerning FH in Iran. The aim of this study was to characterize the LDLR and APOB gene mutations in an Iranian population. A total of 30 non-related… CONTINUE READING