Molecular Characterization of Dendritic Cell-derived Exosomes : Selective Accumulation of the Heat Shock Protein hsc 73

@inproceedings{Thry1999MolecularCO,
  title={Molecular Characterization of Dendritic Cell-derived Exosomes : Selective Accumulation of the Heat Shock Protein hsc 73},
  author={Clotilde Th{\'e}ry and Armelle R{\'e}gnault and J{\'e}r{\^o}me Garin and Joseph Wolfers and Laurence Zitvogel and Paola Ricciardi-Castagnoli and Graça Raposo and S{\'e}bastian Amigorena},
  year={1999}
}
Exosomes are membrane vesicles secreted by hematopoietic cells upon fusion of late multivesicular endosomes with the plasma membrane. Dendritic cell (DC)-derived exosomes induce potent antitumor immune responses in mice, resulting in the regression of established tumors (Zitvogel, L., A. Regnault, A. Lozier, J. Wolfers, C. Flament, D. Tenza, P. Ricciardi-Castagnoli, G. Raposo, and S. Amigorena. 1998. Nat. Med. 4:594–600). To unravel the molecular basis of exosomeinduced immune stimulation, we… CONTINUE READING