Molecular Characterization of Apocrine Salivary Duct Carcinoma

@article{Chiosea2015MolecularCO,
  title={Molecular Characterization of Apocrine Salivary Duct Carcinoma},
  author={S. Chiosea and Lindsay D. Williams and Christopher C. Griffith and L. Thompson and I. Weinreb and J. Bauman and Alyssa Luvison and S. Roy and R. Seethala and M. Nikiforova},
  journal={The American Journal of Surgical Pathology},
  year={2015},
  volume={39},
  pages={744–752}
}
  • S. Chiosea, Lindsay D. Williams, +7 authors M. Nikiforova
  • Published 2015
  • Biology, Medicine
  • The American Journal of Surgical Pathology
  • Contemporary classification and treatment of salivary duct carcinoma (SDC) require its thorough molecular characterization. Thirty apocrine SDCs were analyzed by the Ion Ampliseq Cancer HotSpot panel v2 for mutations in 50 cancer-related genes. Mutational findings were corroborated by immunohistochemistry (eg, TP53, BRAF, &bgr;-catenin, estrogen, and androgen receptors) or Sanger sequencing/SNaPshot polymerase chain reaction. ERBB2 (HER2), PTEN, FGFR1, CDKN2A/P16, CMET, EGFR, MDM2, and PIK3CA… CONTINUE READING
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