Molecular Characterization of Apocrine Salivary Duct Carcinoma

  title={Molecular Characterization of Apocrine Salivary Duct Carcinoma},
  author={S. Chiosea and Lindsay D. Williams and Christopher C. Griffith and L. Thompson and I. Weinreb and J. Bauman and Alyssa Luvison and S. Roy and R. Seethala and M. Nikiforova},
  journal={The American Journal of Surgical Pathology},
  • S. Chiosea, Lindsay D. Williams, +7 authors M. Nikiforova
  • Published 2015
  • Biology, Medicine
  • The American Journal of Surgical Pathology
  • Contemporary classification and treatment of salivary duct carcinoma (SDC) require its thorough molecular characterization. Thirty apocrine SDCs were analyzed by the Ion Ampliseq Cancer HotSpot panel v2 for mutations in 50 cancer-related genes. Mutational findings were corroborated by immunohistochemistry (eg, TP53, BRAF, &bgr;-catenin, estrogen, and androgen receptors) or Sanger sequencing/SNaPshot polymerase chain reaction. ERBB2 (HER2), PTEN, FGFR1, CDKN2A/P16, CMET, EGFR, MDM2, and PIK3CA… CONTINUE READING
    55 Citations
    Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer
    • 86
    • PDF
    MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas
    • 9
    • PDF
    Integrative genomic analysis of salivary duct carcinoma
    • PDF
    Recurrent RET Gene Rearrangements in Intraductal Carcinomas of Salivary Gland
    • 36
    Somatic mutations in salivary duct carcinoma and potential therapeutic targets.
    • 15
    • Highly Influenced
    • PDF


    High-throughput profiling identifies clinically actionable mutations in salivary duct carcinoma
    • 34
    PIK3CA Mutations and PTEN Loss in Salivary Duct Carcinomas
    • 46
    p53 mutations and overexpression in locally advanced breast cancers.
    • 77
    • PDF
    Detection of Novel Actionable Genetic Changes in Salivary Duct Carcinoma Helps Direct Patient Treatment
    • 89
    • PDF
    Expression and mutational status of treatment-relevant targets and key oncogenes in 123 malignant salivary gland tumours.
    • J. Cros, E. Sbidian, +8 authors C. Badoual
    • Medicine
    • Annals of oncology : official journal of the European Society for Medical Oncology
    • 2013
    • 53