Molecular Characteristics of Clostridium perfringens TpeL Toxin and Consequences of Mono-O-GlcNAcylation of Ras in Living Cells*

@article{Guttenberg2012MolecularCO,
  title={Molecular Characteristics of Clostridium perfringens TpeL Toxin and Consequences of Mono-O-GlcNAcylation of Ras in Living Cells*},
  author={G. Guttenberg and S. Hornei and T. Jank and Carsten Schwan and Wei L{\"u} and O. Einsle and P. Papatheodorou and K. Aktories},
  journal={The Journal of Biological Chemistry},
  year={2012},
  volume={287},
  pages={24929 - 24940}
}
Background: TpeL is a member of the family of clostridial glucosylating toxins, produced by Clostridium perfringens. Results: TpeL enters target cells by self-mediated entry and mono-glycosylates Ras proteins at Thr-35. Conclusion: TpeL inhibits Ras signaling and induces apoptosis in target cells. Significance: TpeL is a new glucosylating toxin produced by C. perfringens. TpeL is a member of the family of clostridial glucosylating toxins produced by Clostridium perfringens type A, B, and C… Expand
Characterization of the enzymatic activity of Clostridium perfringens TpeL.
LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins
Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL
Clostridium difficile Toxin Biology.
Toxin Plasmids of Clostridium perfringens
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