Molecular Cellular Mechanisms of Peptide Regulation of Melatonin Synthesis in Pinealocyte Culture

@article{Khavinson2012MolecularCM,
  title={Molecular Cellular Mechanisms of Peptide Regulation of Melatonin Synthesis in Pinealocyte Culture},
  author={V. Kh. Khavinson and Natalia Linkova and I. M. Kvetnoy and Tatiana V. Kvetnaia and Victoria O. Polyakova and Horst-Werner Korf},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2012},
  volume={153},
  pages={255-258}
}
The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture. Epithalone stimulated AANAT and pCREB synthesis and increased melatonin level in culture medium. Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB. 
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References

SHOWING 1-10 OF 23 REFERENCES
Melatonin—A pleiotropic, orchestrating regulator molecule
TLDR
Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging. Expand
Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas
TLDR
Epitalon is a promising factor for restoring the age-related endocrine dysfunctions of primates with the help of epitalon, a synthetic analogue of the pharmacopoeia drug epithalamin. Expand
Melatonin Metabolism in the Central Nervous System
TLDR
The relative contribution of the various pathways to melatonin catabolism seems to be influenced by microglia activation, oxidative stress and brain levels of melatonin, which may be strongly changed in experiments on neuroprotection. Expand
Peptide bioregulation of aging: results and prospects
TLDR
It was shown that long-term treatment with some peptide preparations increased mean life span by 20–40%, slow down the age-related changes in the biomarkers of aging and suppressed development of spontaneous and induced by chemical or radiation carcinogens tumorigenesis in rodents. Expand
Gerontological Aspects of Genome Peptide Regulation
TLDR
Complementary Interaction between Small Peptides and DNA Informational Interaction in the 'Peptide - DNA' System From Anti-Aging Peptide Regulation to Pharmacogenomics Conclusion References Subject Index. Expand
Changes in Apoptosis and Cell Proliferation in Human Pineal Gland during Aging
Immunohistochemical analysis of the expression of proapoptotic protein P53 and proliferation protein Ki-67 in human pineal gland showed that in people over 60 years pinealocyte proliferation isExpand
Peptide Geroprotector from the Pituitary Gland Inhibits Rapid Aging of Elderly People: Results of 15-Year Follow-Up
TLDR
Long-term treatment with epithalamin (6 courses over 3 years) decelerated aging of the cardiovascular system, prevented age-associated impairment of physical endurance, normalized circadian rhythm of melatonin production and carbohydrate and lipid metabolism. Expand
Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity
The main component of senile plaques in Alzheimer's disease (AD), aggregated amyloid beta peptide (βA), is neurotoxic and implicated in AD pathology. Melatonin is a hormone secreted from the pinealExpand
Melatonin and aging: prospects for human treatment.
  • G. Bubenik, S. Konturek
  • Biology, Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2011
TLDR
It was hypothesized that the reduction ofmelatonin levels with age contributes to the aging process, and a daily intake of melatonin before bed time might achieve the same effect as fasting e.g. an increase of body melatonin levels, which will protect the individual from the ravages of old age. Expand
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