Molecular Cancer esearch cer Genes and Genomics ational and Functional Analysis Reveals ADAMTS 18 R alloproteinase as a Novel Driver in Melanoma

@inproceedings{Wei2010MolecularCE,
  title={Molecular Cancer esearch cer Genes and Genomics ational and Functional Analysis Reveals ADAMTS 18 R alloproteinase as a Novel Driver in Melanoma},
  author={Un Wei and Todd D. Prickett and Cristina Guti{\'e}rrez Viloria and Alfredo A Molinolo and Jimmy Cheng-Ho Lin and Isabel Cardenas-Navia and Cruz and Steven A Rosenberg and Michael A. Davies and E. Gershenwald and Carlos L{\'o}pez-Ot{\'i}n and Yardena Samuels},
  year={2010}
}
ownload disintegrin-metalloproteinases with thrombospondin domains (ADAMTS) genes have been suggested to n as tumor suppressors as several have been found to be epigenetically silenced in various cancers. We med a mutational analysis of the ADAMTS gene family in human melanoma and identified a large fraction lanomas to harbor somatic mutations. To evaluate the functional consequences of the most commonly ed gene, ADAMTS18, six of its mutations were biologically examined. ADAMTS18 mutations had… CONTINUE READING