Molecular Brain-Derived Neurotrophic Factor Modulates Fast Synaptic Inhibition by Regulating GABAA Receptor Phosphorylation , Activity , and Cell-Surface Stability

@inproceedings{Jovanovic2004MolecularBN,
  title={Molecular Brain-Derived Neurotrophic Factor Modulates Fast Synaptic Inhibition by Regulating GABAA Receptor Phosphorylation , Activity , and Cell-Surface Stability},
  author={Jasmina N Jovanovic and Philip Thomas and Josef T Kittler and Trevor G Smart and Stephen J. Moss},
  year={2004}
}
The efficacy of GABAergic synaptic inhibition is a principal factor in controlling neuronal activity. We demonstrate here that brainderived neurotrophic factor modulates the activity of GABAA receptors, the main sites of fast synaptic inhibition in the brain, within minutes of application. Temporally, this comprised an early enhancement in the miniature IPSC amplitude, followed by a prolonged depression. This modulation was concurrent with enhanced PKC-mediated phosphorylation, followed by… CONTINUE READING

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