Molecular Biology of Aging

  title={Molecular Biology of Aging},
  author={F. Brad Johnson and David A. Sinclair and Leonard P Guarente},

Figures from this paper

Klotho: a fundamental regulator of aging

HSP70 in Aging

The reduction of HSP70 inducibility most likely reflects the launch of a special genetic program aimed at the activation of JNK-dependent apoptosis and the destruction of old cells, which have accumulated damaged proteins and dangerous mutations.

Oxidative stress and aging in Caenorhabditis elegans.

  • N. Ishii
  • Biology
    Free radical research
  • 2000
The cloned mev-1 gene is found to be the previously sequenced gene (cyt-1) that encodes succinate dehydrogenase cytochrome b, and data suggest that CYT-1 directly participates in electron transport from FADH2 to coenzyme Q.

Mitochondria and Aging—The Role of Exercise as a Countermeasure

Rejuvenation by exercise is a non-pharmacological approach that targets all the major hallmarks of aging and extends both health- and lifespan in modern humans.

Genetics of aging: lessons from centenarians

  • E. Gonos
  • Biology
    Experimental Gerontology
  • 2000

The Werner Syndrome: A Model for the Study of Human Aging

Recent evidence, summarized in this review, suggests specific bio‐chemical roles for this multifaceted protein WRN functions as a DNA helicase, and the interaction of WRN protein with RPA (replication protein A and p53 will undoubtedly direct efforts to further dissect the genetic pathway(s) in which WRNprotein functions in DNA metabolism and will help to unravel its contribution to the human aging process.

Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney.

It is concluded that some changes observed in cellular senescence in vitro do occur in human kidney with age, particularly in the renal cortex, in some cases correlating with histologic features.

Current issues concerning the role of oxidative stress in aging: a perspective.

It is emphasized that extension of life span without simultaneously increasing metabolic potential is of questionable biological significance.

Increased expression of mature cathepsin B in aging rat liver

Findings seem to contradict the present dogma according to which aging tissues have a reduced intracellular capacity to catabolise proteins, and it is proposed that the earlier observation of the accumulation of T-kininogen, a potent but reversible cysteine peptidase inhibitor, in aging rat liver may provide a plausible explanation for this discrepancy.



Aging and resistance to oxidative damage in Caenorhabditis elegans.

  • P. L. Larsen
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
Results support the free radical theory of aging by suggesting that the increased resistance to oxidative stress may be among the causes of increased longevity in both strain TJ401 and in the dauer larva.

The aging process.

  • D. Harman
  • Biology, Medicine
    Basic life sciences
  • 1988
It is not unreasonable to expect on the basis of present data that the healthy life span can be increased by 5-10 or more years by keeping body weight down, at a level compatible with a sense of well-being, while ingesting diets adequate in essential nutrients but designed to minimize random free radical reactions in the body.

Replicative senescence in the immune system: impact of the Hayflick limit on T-cell function in the elderly.

  • R. Effros
  • Biology
    American journal of human genetics
  • 1998
It is argued that T-cell replicativesenescence contributes to increased morbidity and mor-tality during aging and that the proportion of replica cells in the immune system should be reduced.

What Does Cell Death Have To Do with Aging?

The results currently available suggest that apoptosis is a process that may be important in aging, at least in some tissues, and the mechanism of its regulation, in particular, needs to be understood.

Endocrinology in aging.

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

The wild-type Caenorhabditis elegans nematode ages rapidly, undergoing development, senescence, and death in less than 3 weeks. In contrast, mutants with reduced activity of the gene daf-2, a homolog

Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

These studies show a direct age‐related correlation between a biochemical and genetic defect in normal human tissues and that mtDNA abnormalities are involved in the aging process in human muscle.

The role of cellular senescence in skin aging.

  • J. Campisi
  • Biology
    The journal of investigative dermatology. Symposium proceedings
  • 1998
Senescent keratinocytes and fibroblasts appear to accumulate with age in human skin, and they express genes that have long-range, pleiotropic effects - degradative enzymes, growth factors, and inflammatory cytokines, which might compromise skin function and integrity.