Molecular Biology of Aging

@article{Johnson1999MolecularBO,
  title={Molecular Biology of Aging},
  author={F. Brad Johnson and David A. Sinclair and Leonard P Guarente},
  journal={Cell},
  year={1999},
  volume={96},
  pages={291-302}
}
1. The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases D.C. Wallace 2. Sirtuins: A Universal Link between NAD, Metabolism, and Aging S.-i. Imai and L. P. Guarente 3. Calorie Restriction in Lower Organisms S.L. Helfand, J.H. Bauer, and J.G. Wood 4. Evolutionary Theory in Aging Research S.N. Austad and T.B.L. Kirkwood 5. An Overview of the Biology of Aging: A Human Perspective G.M. Martin and C.E. Finch 6. p53, Cancer, and Longevity L.A. Donehower and A.J. Levine 7… Expand
Klotho: a fundamental regulator of aging
TLDR
The working hypotheses on the biological roles and molecular functions of Klotho protein are discussed, which show the increased activation of calcium-dependent proteolysis occurs in the tissues of old mice together with the down regulation of klotho gene expression. Expand
HSP70 in Aging
TLDR
The reduction of HSP70 inducibility most likely reflects the launch of a special genetic program aimed at the activation of JNK-dependent apoptosis and the destruction of old cells, which have accumulated damaged proteins and dangerous mutations. Expand
Oxidative stress and aging in Caenorhabditis elegans.
  • N. Ishii
  • Biology, Medicine
  • Free radical research
  • 2000
TLDR
The cloned mev-1 gene is found to be the previously sequenced gene (cyt-1) that encodes succinate dehydrogenase cytochrome b, and data suggest that CYT-1 directly participates in electron transport from FADH2 to coenzyme Q. Expand
Genetics of aging: lessons from centenarians
  • E. Gonos
  • Medicine, Biology
  • Experimental Gerontology
  • 2000
TLDR
The ability of these genes to regulate aging in vitro, in conjunction with the telomeres shortening hypothesis have raised the intriguing question of the existence of a molecular clock that counts and thus may modulates human aging and longevity. Expand
The Werner Syndrome: A Model for the Study of Human Aging
TLDR
Recent evidence, summarized in this review, suggests specific bio‐chemical roles for this multifaceted protein WRN functions as a DNA helicase, and the interaction of WRN protein with RPA (replication protein A and p53 will undoubtedly direct efforts to further dissect the genetic pathway(s) in which WRNprotein functions in DNA metabolism and will help to unravel its contribution to the human aging process. Expand
The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity☆
The genetic analysis of the yeast replicative life span has revealed the importance of metabolic control and resistance to stress. It has also illuminated the pivotal role in determining longevityExpand
Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney.
TLDR
It is concluded that some changes observed in cellular senescence in vitro do occur in human kidney with age, particularly in the renal cortex, in some cases correlating with histologic features. Expand
Current issues concerning the role of oxidative stress in aging: a perspective.
TLDR
It is emphasized that extension of life span without simultaneously increasing metabolic potential is of questionable biological significance. Expand
Increased expression of mature cathepsin B in aging rat liver
TLDR
Findings seem to contradict the present dogma according to which aging tissues have a reduced intracellular capacity to catabolise proteins, and it is proposed that the earlier observation of the accumulation of T-kininogen, a potent but reversible cysteine peptidase inhibitor, in aging rat liver may provide a plausible explanation for this discrepancy. Expand
Molecular and Endocrine Mechanisms Underlying the Stem Cell Theory of Aging
TLDR
It is suggested that not only are stem cells the mediators of aging but are also the best cellular system to study the causes and consequences of aging in mammals. Expand
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