Molecular Biology and Medicine: A Primer for the Clinician

@article{Bello1996MolecularBA,
  title={Molecular Biology and Medicine: A Primer for the Clinician},
  author={E A Bello and Debra A. Schwinn},
  journal={Anesthesiology},
  year={1996},
  volume={85},
  pages={1462-1478.}
}

WHAT WILL MOLECULAR BIOLOGY BRING TO OUR DAILY PRACTICE ?

Bibliometric analysis of original molecular biology research in anaesthesia

TLDR
While in the late 1980s only a few molecular biology articles were published each year by anaesthetic institutions, worldwide this number reached approximately 200 basic science articles by the end of 2002 and the USA clearly dominates the field of anaesthesia with respect to molecular biology research.

Influence of Genotype on Perioperative Risk and Outcome

TLDR
Identification of specific genotypes may not only provide insight as to why the physiologic response to surgery varies among individuals, but it may also potentially decrease surgical morbidity and mortality through preoperative surgical risk assessment and the administration of prophylactic therapy.

The impact of molecular biology on the practice of pediatric critical care medicine.

  • D. WheelerH. Wong
  • Medicine, Biology
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2001
TLDR
"immuno-phenotyping" of critically ill patients will allow for more rational immune-modulating therapies, either in the form of inhibiting or enhancing specific immune/inflammatory responses, and prospects for gene therapy, although quite challenging at present, may be applicable to the intensive care unit in the near future.

Gene Therapy for the Management of Pain: Part I: Methods and Strategies

TLDR
This review summarizes recent developments in gene therapy and demonstrates the possibility of gene therapy for the management of pain, a broad topic requiring expertise in diverse areas of science and medicine.

The future of anesthesiology is perioperative medicine.

  • P. Rock
  • Medicine
    Anesthesiology clinics of North America
  • 2000

References

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Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

TLDR
Overall, a range of correction was seen with restoration of about 50% of the deficit between wild type mice and untreated cf/cf controls, suggesting that this may offer a therapeutic alternative to adenoviral therapies.

The bacteriopbage λ O replication protein: isolation and characterization of the amplified initiator

The bacteriophage lambda O protein participates in the initiation of lambda DNA replication. The lambda O gene was cloned into plasmid pKC30 such that its expression was controlled by the lambda PL

Gene therapy for cancer.

New Alzheimer's gene found.

Large linkage analysis in 100 families with autosomal recessive spinal muscular atrophy (SMA) and 11 CEPH families using 15 polymorphic loci in the region 5q11.2-q13.3.

TLDR
A large genetic linkage study of 100 SMA families and 11 CEPH families using 14 polymorphic simple sequence repeats (SSRs) and one RFLP in the region 5q11.2-q13.3 finds three newly developed polymorphic SSRs and a recently described polymorphic marker too far from the SMA gene to be relevant for cloning.

STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES

TLDR
Evidence is presented that the chemically induced alterations in cellular structure and function are predictable, type-specific, and transmissible in series.
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