Molecular Basis of eRF3 Recognition by the MLLE Domain of Poly(A)-Binding Protein

@inproceedings{Kozlov2010MolecularBO,
  title={Molecular Basis of eRF3 Recognition by the MLLE Domain of Poly(A)-Binding Protein},
  author={Guennadi Kozlov and Kalle Gehring},
  booktitle={PloS one},
  year={2010}
}
PABPC1 (cytosolic poly(A)-binding protein 1) is an RNA-binding protein that binds to the poly(A) tail of mRNAs to promote translation and mRNA turnover. In addition to RNA-binding domains, PABPC1 contains a unique protein-protein interaction domain, MLLE (also known as PABC) that binds regulatory proteins and translation factors that contain a conserved 12 amino acid peptide motif termed PAM2. Eukaryotic Release Factor 3 (eRF3/GSPT1) contains two overlapping PAM2 sequences, which are required… CONTINUE READING
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