Molecular Basis of Growth Hormone Action

  title={Molecular Basis of Growth Hormone Action},
  author={Christin Carter-Su and Xiangdong Wang and Gaylon S. Campbell and Lawrence S Argetsinger and Nils Billestrup and Gunnar Norstedt and Debra Meyer and Jacquie Schwartz},
  journal={Pediatric Research},
The intracellular pathways by which binding of GH to its receptor elicits its diverse effects on growth, differentiation and metabolism have eluded investigators for many years. We have hypothesized that activation by GH of a GH receptor (GHR)-associated tyrosine kinase is an important early, and perhaps, initiating step in signal transduction by GH. This… CONTINUE READING