Molecular Basis of Amplification in Drosophila Phototransduction Roles for G Protein, Phospholipase C, and Diacylglycerol Kinase

@article{Hardie2002MolecularBO,
  title={Molecular Basis of Amplification in Drosophila Phototransduction Roles for G Protein, Phospholipase C, and Diacylglycerol Kinase},
  author={Roger C. Hardie and Fernando Tadeu Bueno Martin and Gary Cochrane and Mikko Juusola and Plamen Ivanchev Georgiev and Padinjat Raghu},
  journal={Neuron},
  year={2002},
  volume={36},
  pages={689-701}
}
In Drosophila photoreceptors, the amplification responsible for generating quantum bumps in response to photoisomerization of single rhodopsin molecules has been thought to be mediated downstream of phospholipase C (PLC), since bump amplitudes were reportedly unaffected in mutants with greatly reduced levels of either G protein or PLC. We now find that quantum bumps in such mutants are reduced approximately 3- to 5-fold but are restored to near wild-type values by mutations in the rdgA gene… CONTINUE READING