Molecular Basis for the Lack of HERG K 1 Channel Block-Related Cardiotoxicity by the H 1 Receptor Blocker Cetirizine Compared with Other Second-Generation Antihistamines

In the current study, the potential blocking ability of K channels encoded by the human ether-a-go-go related gene (HERG) by the piperazine H1 receptor antagonist cetirizine has been examined and compared with that of other second-generation antihistamines (astemizole, terfenadine, and loratadine). Cetirizine was completely devoid of any inhibitory action… CONTINUE READING