Molecular Basis for Transmission Barrier and Interference between Closely Related Prion Proteins in Yeast*


Replicating amyloids, called prions, are responsible for transmissible neurodegenerative diseases in mammals and some heritable phenotypes in fungi. The transmission of prions between species is usually inhibited, being highly sensitive to small differences in amino acid sequence of the prion-forming proteins. To understand the molecular basis of this prion… (More)
DOI: 10.1074/jbc.M110.183889