Molecular Basis for Selective Serotonin Reuptake Inhibition by the Antidepressant Agent Fluoxetine ( Prozac ) s

@inproceedings{Andersen2014MolecularBF,
  title={Molecular Basis for Selective Serotonin Reuptake Inhibition by the Antidepressant Agent Fluoxetine ( Prozac ) s},
  author={Jacob Andersen and Nicolai Stuhr-Hansen and Linda Gr\onborg Zachariassen and Heidi Kolds\o and Birgit Schi\ott and Kristian Str\omgaard and Anders S Kristensen},
  year={2014}
}
Inhibitors of the serotonin transporter (SERT) are widely used antidepressant agents, but the structural mechanism for inhibitory activity and selectivity over the closely related norepinephrine transporter (NET) is not well understood. Here we use a combination of chemical, biological, and computational methods to decipher the molecular basis for high… CONTINUE READING