Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase

@article{Szyk2014MolecularBF,
  title={Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase},
  author={Agnieszka Szyk and Alexandra M Deaconescu and Jeffrey O. Spector and Benjamin Goodman and Max L. Valenstein and Natasza E. Ziolkowska and Vasilisa Kormendi and Nikolaus Grigorieff and Antonina Roll-Mecak},
  journal={Cell},
  year={2014},
  volume={157},
  pages={1405-1415}
}
Acetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known posttranslational modification in the microtubule lumen. It marks stable microtubules and is required for polarity establishment and directional migration. Here, we elucidate the mechanistic underpinnings for TAT activity and its preference for microtubules with slow turnover. 1.35 Å TAT cocrystal structures with bisubstrate analogs constrain TAT action to the microtubule lumen and reveal Lys40 engaged in a… CONTINUE READING
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