Molecular Basis and Regulation of OTULIN-LUBAC Interaction

  title={Molecular Basis and Regulation of OTULIN-LUBAC Interaction},
  author={Paul Ronald Elliott and Sofie Vincents Nielsen and Paola Marco-Casanova and Berthe Katrine Fiil and Kirstin Keusekotten and Niels Mailand and Stefan Freund and Mads Gyrd-Hansen and David Komander},
  booktitle={Molecular cell},
The linear ubiquitin (Ub) chain assembly complex (LUBAC) generates Met1-linked "linear" Ub chains that regulate the activation of the nuclear factor κB (NFκB) transcription factor and other processes. We recently discovered OTULIN as a deubiquitinase that specifically cleaves Met1-linked polyUb. Now, we show that OTULIN binds via a conserved PUB-interacting motif (PIM) to the PUB domain of the LUBAC component HOIP. Crystal structures and nuclear magnetic resonance experiments reveal the… CONTINUE READING
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