2,641 Citations
Molecular Genetics of Circadian Rhythms in Neurospora , a Prototypic Circadian System
- Biology
- 2001
This section tries to cut through the complexity of circadian systems to the basic molecular issues defining and governing circadian timing at the biochemical level.
Understanding circadian rhythmicity in Neurospora crassa: from behavior to genes and back again.
- BiologyFungal genetics and biology : FG & B
- 2000
The lessons learned in Neurospora are relevant to the understanding of clocks in higher eukaryotes and the mechanisms by which the clock is kept in synchrony with the environment.
The circadian clock of the fly: a neurogenetics journey through time.
- BiologyAdvances in genetics
- 2012
Molecular mechanism and cellular distribution of insect circadian clocks.
- BiologyAnnual review of entomology
- 2000
Investigation of whether nonneural tissues possess intrinsic circadian clocks, what role they may be playing, and what the relationships are between clocks in the nervous system and those in peripheral tissues are providing important insights into the overall organization of the circadian system in insects.
Principles of the animal molecular clock learned from Neurospora
- BiologyThe European journal of neuroscience
- 2019
This model system has contributed to the current appreciation of the role of Intrinsic Disorder in clock proteins and to the documentation of the essential roles of protein post‐translational modification, as distinct from turnover, in building a circadian clock.
Genetic and molecular analysis of circadian rhythms in Neurospora.
- BiologyAnnual review of physiology
- 2001
Neurospora promises to be a suitable system for examining the role of coupled feedback loops in the clock and to be at the forefront of studies aimed at understanding clock control of gene expression.
Around the Fungal Clock: Recent Advances in the Molecular Study of Circadian Clocks in Neurospora and Other Fungi.
- BiologyAdvances in genetics
- 2015
Circadian clocks--from genes to complex behaviour.
- BiologyReproduction, nutrition, development
- 1999
Now that the reductionist approach has led to the description of a detailed clock model at the molecular level, further insights into the circadian system can be provided by combining the extensive knowledge gained from decades of physiological research with molecular tools, thereby reconstructing the clock within the organism and its environment.
Molecular genetic analysis of circadian timekeeping in Drosophila.
- BiologyAdvances in genetics
- 2011
Molecular components of the circadian system in Drosophila.
- BiologyAnnual review of physiology
- 2001
It has, however, become clear that in addition to the brain clock, autonomous or semi-autonomous clocks occur in peripheral tissues where they confer circadian regulation on specific functions.
References
SHOWING 1-10 OF 422 REFERENCES
Genetics and molecular analysis of circadian rhythms.
- BiologyAnnual review of genetics
- 1996
Two best understood aspects of the two best understood circadian systems, the feedback oscillators of Neurospora and Drosophila are summarized, concentrating on what the authors know about the frequency (frq), period (per) and timeless (tim) genes.
Differential Effects of Light and Heat on theDrosophila Circadian Clock Proteins PER and TIM
- BiologyMolecular and Cellular Biology
- 1998
These findings can account for the lack of apparent steady-state shifts in Drosophila behavioral rhythms by heat pulses applied in the late night and strongly suggest that stimulus-induced changes in the speed of circadian clocks can contribute to phase-shifting responses.
Trippings along the trail to the molecular mechanisms of biological clocks
- BiologyTrends in Neurosciences
- 1995
The molecular control of circadian behavioral rhythms and their entrainment in Drosophila.
- BiologyAnnual review of biochemistry
- 1998
The recent discovery of PER homologues in mice and humans suggests that a related mechanism controls mammalian circadian behavioral rhythms.
Neurospora wc-1 and wc-2: transcription, photoresponses, and the origins of circadian rhythmicity.
- BiologyScience
- 1997
DNA binding and transcriptional activation can now be associated with a clock gene that may provide a positive element in the feedback loop, and similarities between the PAS-domain regions of molecules involved in light perception and circadian rhythmicity in several organisms suggest an evolutionary link between ancient photoreceptor proteins and more modern proteins required for circadian oscillation.
Circadian clock-controlled genes isolated from Neurospora crassa are late night- to early morning-specific.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1996
A major role for the clock is suggested in the regulation of biological processes distinct from development, including rhythmic control of genes involved in clock output pathways in the fungus Neurospora crassa.
Circadian oscillation of a mammalian homologue of the Drosophila period gene
- BiologyNature
- 1997
The human and mouse genes (hPER and mPer, respectively) encoding PAS-domain (PAS, a dimerization domain present in Per, Amt and Sim)-containing polypeptides that are highly homologous to dPer are identified.
Molecular Circadian Oscillators: An Alternative Hypothesis
- BiologyJournal of biological rhythms
- 1998
A model placing an autoregulatory gene and its products on an input pathway feeding into a separate oscillator can explain the majority of results of molecular circadian biology published to date.
New Timepiece Has a Familiar Ring
- BiologyScience
- 1998
Researchers in Japan describe the workings of the biological clock of the single-celled organisms known as cyanobacteria, or blue-green algae, and find that the clock is based on the same working principle as are those of fruit flies, mammals, and the bread mold Neurospora.