Molecular Assessment of Clonality in Lymphoproliferative Disorders: I. Immunoglobulin Gene Rearrangements.

@article{Coad1996MolecularAO,
  title={Molecular Assessment of Clonality in Lymphoproliferative Disorders: I. Immunoglobulin Gene Rearrangements.},
  author={Coad and Olson and Lander and McGLENNEN},
  journal={Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology},
  year={1996},
  volume={1 4},
  pages={335-355}
}
  • Coad, Olson, +1 author McGLENNEN
  • Published 1996 in
    Molecular diagnosis : a journal devoted to the…
The non-Hodgkins' lymphomas are a diverse group of malignancies with characteristic clinical and laboratory features. The routine evaluation of these lesions includes histologic and immunophenotypic analyses. In the small percentage of cases that pose diagnostic challenges, the algorithm can include molecular genetic studies to help render a diagnosis. Unique immunoglobulin heavy- and light-chain or T-cell-receptor gene rearrangements are used to establish clonality in B- and T-cell… CONTINUE READING
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