Molecular Aspects of Regulation of Collagen Gene Expression in Fibrosis

@article{Bhogal2005MolecularAO,
  title={Molecular Aspects of Regulation of Collagen Gene Expression in Fibrosis},
  author={Rashpal K. Bhogal and Cristina Stoica and Tracy L McGaha and Constantin A. Bona},
  journal={Journal of Clinical Immunology},
  year={2005},
  volume={25},
  pages={592-603}
}
Fibrosis, the hyper-accumulation of scar tissue, is characterized by the overproduction and deposition of type I and III collagen by fibroblasts and is the one of the main pathologic outcomes of the autoimmune disorder scleroderma. While the causes of fibrosis in scleroderma are unknown, cytokines such as TGF-β, IL-4 and IL-13, play a crucial role in the… CONTINUE READING