Molecular Aspects of Polyene- and Sterol-Dependent Pore Formation in Thin Lipid Membranes

@article{Dennis1970MolecularAO,
  title={Molecular Aspects of Polyene- and Sterol-Dependent Pore Formation in Thin Lipid Membranes},
  author={Vincent W. Dennis and Nancy W. Stead and Thomas E. Andreoli},
  journal={The Journal of General Physiology},
  year={1970},
  volume={55},
  pages={375 - 400}
}
Amphotericin B modifies the permeability properties of thin lipid membranes formed from solutions containing sheep red cell phospholipids and cholesterol. At 10-6 M amphotericin B, the DC membrane resistance fell from ≈108 to ≈102 ohm-cm2, and the membranes became Cl--, rather than Na+-selective; the permeability coefficients for hydrophilic nonelectrolytes increased in inverse relationship to solute size, and the rate of water flow during osmosis increased 30-fold. These changes may be… 
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Transient permeability induced by alkyl derivatives of amphotericin B in lipid membranes.

Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. I. Specificity of the membrane permeability changes induced by the polyene antibiotics.

Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. 3. Molecular structure of the polyene antibiotic-cholesterol complexes.

Polyene antibiotic-sterol interactions in membranes of Acholesplasma laidlawii cells and lecithin liposomes. II. Temperature dependence of the polyene antibiotic-sterol complex formation.

Interaction of the polyene antibiotics with lipid bilayer vesicles containing cholesterol.

Selective release of non-electrolytes from liposomes upon perturbation of bilayers by temperature change or polyene antibiotics.

Effect of Membrane Structure on the Action of Polyenes: I. Nystatin Action in Cholesterol- and Ergosterol-Containing Membranes

The present results and those of a companion paper lead us to propose that membrane structure is the determining factor for drug selectivity in membranes with different sterols.

How do ionic channel properties depend on the structure of polyene antibiotic molecules?

Properties of amphotericin B channels in a lipid bilayer.

How does Amphotericin B Work?: Studies on Model Membrane Systems

AbstractThe drug Amphotericin B is a very important antifungal agent as well as one of the first model systems for transmembrane pore structures. The most widely accepted model for the anticellular…
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References

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