Molecular Aspects of Polyene- and Sterol-Dependent Pore Formation in Thin Lipid Membranes

  title={Molecular Aspects of Polyene- and Sterol-Dependent Pore Formation in Thin Lipid Membranes},
  author={Vincent W. Dennis and Nancy W. Stead and Thomas E. Andreoli},
  journal={The Journal of General Physiology},
  pages={375 - 400}
Amphotericin B modifies the permeability properties of thin lipid membranes formed from solutions containing sheep red cell phospholipids and cholesterol. At 10-6 M amphotericin B, the DC membrane resistance fell from ≈108 to ≈102 ohm-cm2, and the membranes became Cl--, rather than Na+-selective; the permeability coefficients for hydrophilic nonelectrolytes increased in inverse relationship to solute size, and the rate of water flow during osmosis increased 30-fold. These changes may be… 

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