Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1

  title={Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1},
  author={Georg F. Weber},
  • G. Weber
  • Published 10 March 2015
  • Biology, Medicine
  • Sarcoma
A patient presented with a recurrent sarcoma (diagnosed as leiomyosarcoma) 12 years after the removal of an initial cancer (diagnosed as extracompartmental osteosarcoma) distally on the same limb. Following surgery, the sarcoma and unaffected muscle and bone were subjected to measurements of DNA exome sequence, RNA and protein expression, and transcription factor binding. The investigation provided corroboration of the diagnosis leiomyosarcoma, as the major upregulations in this tumor compriseโ€ฆย 

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