Molecular Analyses of Possible Mechanisms Coding for Low-Level Mupirocin Resistance in Clinical Staphylococcus aureus Isolates

Abstract

The topical agent mupirocin plays a crucial role in strategies designed to control outbreaks of methicillinresistant Staphylococcus aureus (MRSA) [1]. Mupirocin (pseudomonic acid A) is an analogue of isoleucine that competitively binds to isoleucyl-tRNA synthetase (IRS), inhibiting protein synthesis. Inhibition of IRS is irreversible and time-dependent, suggesting that the mupirocin-IRS complex is highly stable. The IRS protein is encoded by the its gene [2].

DOI: 10.1007/s100960000327

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Cite this paper

@article{Schmitz2000MolecularAO, title={Molecular Analyses of Possible Mechanisms Coding for Low-Level Mupirocin Resistance in Clinical Staphylococcus aureus Isolates}, author={F. -J. Schmitz and Ad C. Fluit and E. Lindenlauf and Sybille Scheuring and Karl K{\"{o}hrer}, journal={European Journal of Clinical Microbiology and Infectious Diseases}, year={2000}, volume={19}, pages={649-650} }