Molecular Adsorbent Recirculating System (MARS) Application in Liver Failure: Clinical and Hemodepurative Results in 22 Patients

@article{Stefoni2006MolecularAR,
  title={Molecular Adsorbent Recirculating System (MARS) Application in Liver Failure: Clinical and Hemodepurative Results in 22 Patients},
  author={Sergio Stefoni and Luigi Col{\`i} and Luigi Bolondi and Gabriele Donati and Giovanni Ruggeri and Giorgio Feliciangeli and Fabio Piscaglia and Elena Silvagni and M. Sirri and Gabriele Donati and Olga Baraldi and M L Soverini and Giuseppe Cianciolo and Paola Boni and D. Patrono and Eric Ramazzotti and R. Motta and Amparo Roda and Patrizia Simoni and Maria Magliulo and Laura Borgnino and Davide Ricci and D. Mezzopane and Maria Cappuccilli},
  journal={The International Journal of Artificial Organs},
  year={2006},
  volume={29},
  pages={207 - 218}
}
Purpose Acute liver failure (ALF) and acute on chronic liver failure (ACLF) still show a poor prognosis. MARS was used in 22 patients with ALF or ACLF to prolong patient survival for liver function recovery or as a bridge to transplantation. Design Evaluation of depurative efficiency, biocompatibility, hemodynamics, encephalopathy (HE) and clinical outcome. Procedures During 71 five-hour sessions we evaluated (0′, 60′, 120′, 180′, 240′, 300′): bilirubin, ammonia, cholic acid (CCA… 
Extracorporeal detoxification for hepatic failure using molecular adsorbent recirculating system: depurative efficiency and clinical results in a long-term follow-up.
TLDR
In conclusion, MARS was clinically well tolerated by all patients and significantly reduced hepatic toxins and growth factors, but patients' clinical characteristics on starting MARS therapy were the main factors predicting survival.
[Usefulness and safety of extracorporeal liver support therapy using MARSR for patients with liver failure: a preliminary report].
  • J. Choi, K. Yoon, +7 authors D. Y. Kim
  • Medicine
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • 2009
TLDR
In patients with liver failure, MARSR improved the laboratory data and hepatic and renal function associated clinical characteristics but did not improve survival, suggesting that MARSR may be useful as a bridge therapy to liver transplantation in patients with Liver failure.
Detoxification of bilirubin and bile acids with intermittent coupled plasmafiltration and adsorption in liver failure (HERCOLE study)
TLDR
CPFA resulted to be effective in liver detoxification and may be considered as a “bridge technique” both to the liver transplant and to the recovery of the basal liver function.
Extracorporeal liver support-albumin dialysis with the Molecular Adsorbent Recirculating System (MARS).
Extracorporeal liver support has been a much studied topic throughout the last 50 years. Albumin dialysis as a therapeutic option for patients with acute liver failure or acute decompensation of
Albumin Dialysis MARS: Knowledge from 10 Years of Clinical Investigation
TLDR
Together, albumin dialysis represents a valuable therapeutic tool for the treatment of various types of liver failure and ongoing and future studies will help define the optimal patient selection and technical process parameters such as session length and frequency of treatment.
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TLDR
There is a lack of standardization of indications for ECLAD, availability of different extracorporeal devices with varied technical approaches, and, of note, the differences in doses of ECLad provided in clinical practice.
MARS: Should I Use It?
TLDR
This review aims to discuss the controversies, potential benefits, practicalities, and disadvantages of using MARS in clinical practice.
Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: a randomized controlled study.
TLDR
Extra-corporal liver support with Prometheus is proven to be safe in patients with endstage liver disease but does not exert the beneficial effects on arterial pressure as seen in the MARS group.
Hybrid Extracorporeal Therapies as a Bridge to Pediatric Liver Transplantation*
  • Ayse Akcan Arikan, P. Srivaths, +7 authors Moreshwar S Desai
  • Medicine
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2018
Objectives: Standard intensive care treatment is inadequate to keep children with liver failure alive without catastrophic complications to ensure successful transplant, as accumulation of endogenous
Albumin dialysis: an update
  • S. Mitzner
  • Medicine
    Current opinion in nephrology and hypertension
  • 2007
TLDR
Albumin regeneration has developed into a central component of modern liver support technologies and is the most frequently used and best studied liver support technique at present time.
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