Molecular Activation of Protein Kinase C in Sensory Neurons Accelerates Ca 2 Uptake into the Endoplasmic Reticulum

@inproceedings{Usachev2005MolecularAO,
  title={Molecular Activation of Protein Kinase C in Sensory Neurons Accelerates Ca 2 Uptake into the Endoplasmic Reticulum},
  author={Yuriy M Usachev and Anthony J. Marsh and Tanner M. Johanns and Michelle M. Lemke and Stanley A Thayer},
  year={2005}
}
The rate of Ca 2 clearance from the neuronal cytoplasm affects the amplitude, duration, and localization of Ca 2 signals and influences a variety of Ca 2 -dependent functions. We reported previously that activation of protein kinase C (PKC) accelerates Ca 2 efflux in rat sensory neurons mediated by the plasma membrane Ca 2 -ATPase isoform 4 (PMCA4). Here we show that sarco-endoplasmic reticulum Ca 2 -ATPase (SERCA)-mediated Ca 2 uptake into intracellular stores is also accelerated by PKC… CONTINUE READING
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