Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.

@article{Hartmann2016MolecularAO,
  title={Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.},
  author={Kerstin Hartmann and Mascha Koenen and Sebastian Schauer and Stephanie M. Wittig-Blaich and Mubashir Ahmad and Ulrike Baschant and Jan P Tuckermann},
  journal={Physiological reviews},
  year={2016},
  volume={96 2},
  pages={
          409-47
        }
}
Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that are frequently used to treat inflammatory diseases. Major complications associated with long-term steroid therapy include impairment of cartilaginous bone growth and GC-induced osteoporosis. Particularly in arthritis, GC application can increase joint and bone damage. Contrarily, endogenous GC release supports cartilage and bone integrity. In the last decade, substantial progress in the understanding of the… 

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