Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.

  title={Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.},
  author={Kerstin Hartmann and Mascha Koenen and Sebastian Schauer and Stephanie M. Wittig-Blaich and Mubashir Ahmad and Ulrike Baschant and Jan P Tuckermann},
  journal={Physiological reviews},
  volume={96 2},
Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that are frequently used to treat inflammatory diseases. Major complications associated with long-term steroid therapy include impairment of cartilaginous bone growth and GC-induced osteoporosis. Particularly in arthritis, GC application can increase joint and bone damage. Contrarily, endogenous GC release supports cartilage and bone integrity. In the last decade, substantial progress in the understanding of the… 

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  • 1998
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Effects of the selective glucocorticoid receptor modulator compound A on bone metabolism and inflammation in male mice with collagen-induced arthritis.

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Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development

This study systematically identifies a spectrum of GC target genes in embryonic growth plate chondrocytes treated with a synthetic GR agonist, dexamethasone (DEX) at 6 and 24 hrs and provides insight into the mechanisms and major molecular classes functioning downstream of DEX in primary chondROcytes.

Selective glucocorticoid receptor modulation maintains bone mineral density in mice

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An anti‐inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

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