Molecular, physiological and clinical aspects of the iron storage protein ferritin.

  title={Molecular, physiological and clinical aspects of the iron storage protein ferritin.},
  author={Koichi Orino and Kiyotaka Watanabe},
  journal={Veterinary journal},
  volume={178 2},
Oxidative stress is a major factor in inflammatory, malignant and metabolic diseases in domestic and farm animals. Oxidative stress-mediated damage depends on the level of cellular and total body iron status because an excess iron (Fe(2+)) pool produces the most harmful free radicals (hydroxyls) through the Fenton reaction. Ferritin is a ubiquitous and conserved iron storage protein that plays a central role in iron metabolism and has the dual function of storing iron in bioavailable and non… CONTINUE READING


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