Molecular, pharmacological and functional diversity of 5-HT receptors

@article{Hoyer2002MolecularPA,
  title={Molecular, pharmacological and functional diversity of 5-HT receptors},
  author={Daniel Hoyer and Jason P. Hannon and Graeme R. Martin},
  journal={Pharmacology Biochemistry and Behavior},
  year={2002},
  volume={71},
  pages={533-554}
}
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Molecular biology of 5-HT receptors

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Pharmacological Analysis in Favour of a Physiological Role for the Constitutive Activity of 5-HT 2A Receptors in Learning

A thorough pharmacological analysis of the available data arguing in favour of the involvement of constitutive activity of 5-HT2A receptors, mostly in learning tasks is proposed and the functional significance of such an activity is discussed.

Functional, molecular and pharmacological advances in 5-HT7 receptor research.

...

References

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It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics, and it is important to rationalise in concert all of the available data from studies involving both operational approaches of the classical pharmacological type and those from molecular and cellular biology.

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The 5-hydroxytryptamine (5-HT; serotonin)4 receptor is one of three 5-HT receptor subtypes that couple positively to adenylyl cyclase, the others being the 5- HT6 and 5-ht7 receptors, which are distinct and have differing distributions and function.

The Pharmacological and Functional Characteristics of the Serotonin 5-HT3A Receptor Are Specifically Modified by a 5-HT3B Receptor Subunit*

The cloning of a subunit 5-HT3B with ∼44% amino acid identity to 5-ht3A that specifically modified 5- HT3Areceptor kinetics, voltage dependence, and pharmacology is reported, suggesting that 5-TT3B might contribute to tissue-specific functional changes in 5-Hat3-mediated signaling and/or modulation.

Molecular biology of 5-HT receptors

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Neurochemical Consequences Following Pharmacological Manipulation of Central 5-HT4 Receptors

The present chapter focuses on the neurochemical functions of central 5-HT4 receptors, a group of receptors comparable to receptor groups responsive to glutamate, GABA and acetylcholine.

The 5-HT3B subunit is a major determinant of serotonin-receptor function

Surprisingly, the M2 region of the 5-HT3B subunit lacks any of the structural features that are known to promote the conductance of related receptors, and will be a valuable resource for defining the molecular mechanisms of ion-channel function.

Molecular biology and potential functional role of 5-HT5, 5-HT6, and 5-HT7 receptors

This review focuses on the structural features, binding properties, and mRNA distribution of these novel 5-HT receptor subtypes, as well as an evaluation of the tool sets available to link these cloned receptors to function and therapeutic potential.

The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists.

A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation and several selective and highly potent full as well as partial agonists emerged.
...