Molecular, pharmacological and functional diversity of 5-HT receptors

@article{Hoyer2002MolecularPA,
  title={Molecular, pharmacological and functional diversity of 5-HT receptors},
  author={D. Hoyer and J. Hannon and G. Martin},
  journal={Pharmacology Biochemistry and Behavior},
  year={2002},
  volume={71},
  pages={533-554}
}
Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors (GPCRs) and one (presumably a family of) ligand-gated ion channel(s). These receptors are divided into seven distinct classes (5-HT(1) to 5-HT(7)) largely on the basis of their structural and operational characteristics. Whilst this degree of physical diversity clearly underscores the physiological importance of… Expand
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