Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake.

@article{Olszewski2010MolecularIA,
  title={Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake.},
  author={Pawel Karol Olszewski and Anica Klockars and Agnieszka M Olszewska and Robert Fredriksson and Helgi B. Schi{\"o}th and Allen Stuart Levine},
  journal={Endocrinology},
  year={2010},
  volume={151 10},
  pages={4736-44}
}
Oxytocin (OT) facilitates feeding termination stemming from high osmolality, stomach distention, and malaise. Recent knockout (KO) studies suggested a crucial function for OT in carbohydrate intake: OT-/- mice had increased preference for carbohydrates, including sucrose, but not fat (Intralipid). In striking contrast, sugar appetite was unaffected in the OT receptor KO mouse; data from wild-type animals have been insufficient. Therefore, we examined the involvement of OT in the regulation of… CONTINUE READING