Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells.

@article{Bastos2005MolecularFA,
  title={Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells.},
  author={Izabela M. D. Bastos and Philippe Grellier and Nat{\'a}lia Florencio Martins and Gloria Cadavid-Restrepo and Marian R de Souza-Ault and Koen Augustyns and Antonio R. L. Teixeira and Joseph Schr{\'e}vel and Bernard Maigret and Jos{\'e} Franco da Silveira and Jaime M. Santana},
  journal={The Biochemical journal},
  year={2005},
  volume={388 Pt 1},
  pages={29-38}
}
We have demonstrated that the 80 kDa POP Tc80 (prolyl oligopeptidase of Trypanosoma cruzi) is involved in the process of cell invasion, since specific inhibitors block parasite entry into non-phagocytic mammalian host cells. In contrast with other POPs, POP Tc80 is capable of hydrolysing large substrates, such as fibronectin and native collagen. In this study, we present the cloning of the POPTc80 gene, whose deduced amino acid sequence shares considerable identity with other members of the POP… CONTINUE READING

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