Molecular, cellular and physiological investigation of myostatin propeptide-mediated muscle growth in adult mice

@article{Matsakas2009MolecularCA,
  title={Molecular, cellular and physiological investigation of myostatin propeptide-mediated muscle growth in adult mice},
  author={Antonios Matsakas and Keith Foster and Anthony Otto and Raymond Macharia and Ketan D Patel},
  journal={Neuromuscular Disorders},
  year={2009},
  volume={19},
  pages={489-499}
}
Inhibition of myostatin signalling or its biological activity has recently emerged as a potential remedial approach against muscle wasting and degenerative diseases such as muscular dystrophies. In the present study we systemically administered a recombinant AAV8 vector expressing a mutated myostatin propeptide (AAV8ProMyo) to healthy mice in order to assess its impact on the histological, cellular and physiological properties of the skeletal muscle, exploiting the fact that myostatin is… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS

Propeptide-mediated inhibition of myostatin increases muscle mass through inhibiting proteolytic pathways in aged mice.

  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2014
VIEW 3 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

High-level soluble expression of bioactive porcine myostatin propeptide in E. coli

  • Applied Microbiology and Biotechnology
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Muscle Atrophy

  • Advances in Experimental Medicine and Biology
  • 2018
VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2017
VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS