Molecular, cellular, and muscle strip mechanics of the mdx mouse diaphragm.

@article{Bates2013MolecularCA,
  title={Molecular, cellular, and muscle strip mechanics of the mdx mouse diaphragm.},
  author={Genevieve Bates and Sara Sigurdardottir and Linda Hussein Kachmar and Nedjma B. Zitouni and Andrea Benedetti and Basil J Petrof and Dilson E Rassier and Anne-Marie Lauzon},
  journal={American journal of physiology. Cell physiology},
  year={2013},
  volume={304 9},
  pages={
          C873-80
        }
}
Duchenne muscular dystrophy (DMD) is a lethal disorder caused by defects in the dystrophin gene, which leads to respiratory or cardiac muscle failure. Lack of dystrophin predisposes the muscle cell sarcolemmal membrane to mechanical damage. However, the role of myosin in this muscle weakness has been poorly addressed. In the current study, in addition to measuring the velocity of actin filament propulsion (υmax) of mdx myosin molecules purified from 3- and 12-mo-old control (C57Bl/10) and mdx… CONTINUE READING

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Velocity of actomyosin sliding in vitro is reduced in dystrophic mouse diaphragm.

  • American journal of respiratory and critical care medicine
  • 2002
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