Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye.

@article{Lyubarsky2005MoleQO,
  title={Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye.},
  author={Arkady L. Lyubarsky and Andrey B. Savchenko and Sarah B Morocco and Lauren L. Daniele and T Michael Redmond and Edward N Pugh},
  journal={Biochemistry},
  year={2005},
  volume={44 29},
  pages={9880-8}
}
RPE65, a protein expressed in cells of the retinal pigment epithelium of the eye, is essential for the synthesis by isomerohydrolase of 11-cis-retinal, the chromophore of rod and cone opsins. Recent work has established that RPE65 is a retinyl ester binding protein, and as all-trans-retinyl esters are the substrate for isomerohydrolase activity, the hypothesis has emerged that RPE65 serves to deliver substrate to this enzyme or complex. We bred mice with five distinct combinations of the RPE65… CONTINUE READING
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