Mold allergy: is it real and what do we do about it?

@article{Rudert2017MoldAI,
  title={Mold allergy: is it real and what do we do about it?},
  author={Amanda Rudert and Jay M. Portnoy},
  journal={Expert Review of Clinical Immunology},
  year={2017},
  volume={13},
  pages={823 - 835}
}
ABSTRACT Introduction: fungi produce substances that contain pathogen-associated molecular patterns (pamps) and damage-associated molecular patterns (damps) which bind to pattern recognition receptors, stimulating innate immune responses in humans. they also produce allergens that induce production of specific ige. Areas covered: In this review we cover both innate and adaptive immune responses to fungi. Some fungal products can activate both innate and adaptive responses and in doing so, cause… Expand
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References

SHOWING 1-10 OF 106 REFERENCES
Innate and Adaptive Immune Response to Fungal Products and Allergens.
TLDR
To understand what is referred to as allergens from fungal sources, it is necessary to understand how these proteins influence these innate mechanisms and the fact that these mechanisms can bias toward type 2 innate and adaptive immune responses. Expand
Mold Allergens in Respiratory Allergy: From Structure to Therapy
TLDR
Fungi can act as indoor and outdoor respiratory allergen sources, and depending on climate conditions, the rates of sensitization in individuals attending allergy clinics range from 5% to 20%. Expand
The medical effects of mold exposure.
TLDR
A state-of-the-art review of the role that molds are known to play in human disease, including asthma, allergic rhinitis, allergic bronchopulmonary aspergillosis, sinusitis, and hypersensitivity pneumonitis is provided. Expand
Allergy and "toxic mold syndrome".
TLDR
Mold-exposed patients can present with a variety of IgE- and non-IgE-mediated symptoms, and allergic, rather than toxic, responses seemed to be the major cause of symptoms in the studied group. Expand
Exposure and Health Effects of Fungi on Humans.
TLDR
Evidence suggesting that early exposure to dampness or fungi is associated with the development of asthma and increased asthma morbidity is reviewed, providing a rationale for interventions that might be considered for homes and buildings in which there is increased fungal exposure. Expand
Adverse Human Health Effects Associated with Molds in the Indoor Environment
TLDR
Current scientific evidence does not support the proposition that human health has been adversely affected by inhaled mycotoxins in home, school, or office environments, and levels of exposure in the indoor environment, dose-response data in animals, and dose-rate considerations suggest that delivery by the inhalation route of a toxic dose of mycotoxin in the indoors environment is highly unlikely at best. Expand
Antibodies against molds and mycotoxins following exposure to toxigenic fungi in a water-damaged building.
Exposure to molds in water-damaged buildings can cause allergy, asthma, hypersensitivity pneumonitis, mucus membrane irritation, and toxicity--alone or in combination. Despite this, significantExpand
Are indoor molds causing a new disease?
  • A. Terr
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 2004
TLDR
Three mechanisms for disease caused by mold-infection, allergy, and toxicity-are established and well recognized by clinicians and found to lack scientific validity, often on the basis of faulty methodology and insufficient information. Expand
Manufacturing and standardizing fungal allergen products.
  • R. Esch
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 2004
TLDR
The importance of fungal allergen products in the practice of clinical allergy is frequently underestimated and the clinical relevance of this cross-reactivity has been neither fully appreciated nor applied to clinical practice. Expand
Pattern recognition receptors in antifungal immunity
TLDR
This review highlights the importance of PRRs in fungal infection, specifically CLRs, which are the major PRR involved, and describes how genetic aberrations in PRRs can contribute to disease pathology. Expand
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