Moisturizers for Patients with Atopic Dermatitis: An Overview

@article{Sirikudta2013MoisturizersFP,
  title={Moisturizers for Patients with Atopic Dermatitis: An Overview},
  author={Wararat Sirikudta and Kanokvalai Kulthanan and Supenya Varothai and Piyavadee Nuchkull},
  journal={Journal of Allergy and Therapy},
  year={2013},
  volume={4},
  pages={1-6}
}
Atopic dermatitis is a chronic inflammatory skin condition result from epidermal barrier defect and immune dysfunction. Not only has lesional skin increase pH and transepidermal water loss but also non-lesional skin. Regular use of moisturizers helps maintain skin hydration and improve barrier dysfunction. Active ingredients in moisturizers can be classified into occlusives, humectants, and emollients according to their properties. Agents with anti-inflammatory effects are also added. This… 

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References

SHOWING 1-10 OF 58 REFERENCES
Moisturizers for patients with atopic dermatitis.
TLDR
The role and classification of moisturizers is summarized, some ingredients that are commonly added in moisturizers are reviewed, and some ingredients which are claimed to have an anti-inflammatory effects in AD are reviewed.
Moisturizing effects of topical nicotinamide on atopic dry skin
TLDR
The effect of topical nicotinamide on atopic dry skin was examined and the results with the effect of white petrolatum in a left–right comparison study were compared.
Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders
  • M. Lóden
  • Medicine
    American journal of clinical dermatology
  • 2003
TLDR
In double-blind studies moisturizers with urea have been shown to reduce TEWL in atopic and ichthyotic patients and ceramide-dominant lipid mixture improved atopic dermatitis and decreased transepidermal water loss in an open-label study in children.
Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm®)
TLDR
Certain moisturizers could improve skin barrier function in atopics and reduce skin susceptibility to irritants, as measured by TEWL and superficial skin blood flow.
Are the new moisturizers more effective?
TLDR
Moisturizers are recommended to nearly every atopic patient, and should be part of the daily skin care of these patients, as they have the potential to reduce the quantity of topical steroids necessary to keep disease quiescent.
A nonsteroidal lamellar matrix cream containing palmitoylethanolamide for the treatment of atopic dermatitis.
  • L. Kircik
  • Medicine
    Journal of drugs in dermatology : JDD
  • 2010
TLDR
The usefulness of the lamellar matrix cream in reducing time to flare, limiting the use of agents with greater side-effect profiles and lowering the overall cost of treatment is evaluated.
Dry skin and moisturizers.
Comparative trial of moisturizer containing licochalcone A vs. hydrocortisone lotion in the treatment of childhood atopic dermatitis: a pilot study
Background  Although moisturizer usage has been considered a mainstay of treatment for atopic dermatitis (AD) patients, few clinical studies have been investigated. Recently, moisturizers containing
Guidelines for management of atopic dermatitis
TLDR
The present standard therapies for AD consist of the use of topical corticosteroids and tacrolimus ointment as the main treatment for the inflammation, topical application of emollients to treat the cutaneous physiological dysfunction, systemic antihistamines and anti‐allergic drugs as adjunctive treatments for pruritus, avoidance of apparent exacerbating factors, psychological counseling and advice about daily life.
Therapeutic Implications of a Barrier-based Pathogenesis of Atopic Dermatitis.
  • P. Elias
  • Biology
    Annals of dermatology
  • 2010
TLDR
This review provides relevant background information about normal epidermal barrier structure and function and compares various therapeutic paradigms for AD, highlighting the risks and benefits of glucocorticoids and immunomodulators vs. corrective, lipid replacement therapy.
...
...