Moisture sorption kinetics for water-soluble substances. IV: Studies with mixtures of solids.

@article{Kontny1985MoistureSK,
  title={Moisture sorption kinetics for water-soluble substances. IV: Studies with mixtures of solids.},
  author={Mark J. Kontny and George D Zografi},
  journal={Journal of pharmaceutical sciences},
  year={1985},
  volume={74 2},
  pages={124-7}
}
This paper extends earlier work from this laboratory concerning the sorption kinetics of water vapor on deliquescent water-soluble substances to mixtures of these solids. A theoretical model, based on heat transport control, excellently predicted a priori the rate of water uptake by a variety of binary mixtures of alkali halides and sugars. The rates for mixtures containing highly water-soluble quaternary ammonium salts, as either one or both of the components, were less successfully predicted… CONTINUE READING

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It is concluded that water - soluble deliquescent substances , normally encountered in pharmaceutical dosage forms , rapidly form saturated aqueous solutions in the aqueous film formed as water vapor uptake proceeds , and that the water uptake rate can be predicted a priori from known and experimentally determinable parameters using the heat transport model .
It is concluded that water - soluble deliquescent substances , normally encountered in pharmaceutical dosage forms , rapidly form saturated aqueous solutions in the aqueous film formed as water vapor uptake proceeds , and that the water uptake rate can be predicted a priori from known and experimentally determinable parameters using the heat transport model .
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